🧬 The Best of Both Worlds: Depth and Breadth
The BGE product is designed to maximize data utility while keeping costs down. It achieves this by combining two powerful approaches:
- Low Pass Whole Genome (3X coverage): This component analyzes the entire genome at a lower coverage, providing a comprehensive view across all genomic regions. This is invaluable for detecting structural variations, copy number changes, and other large-scale genetic phenomena.
- High-Coverage Whole Exome (40X coverage): Simultaneously, the product delivers a deep, high-coverage look at the exome—the most clinically relevant, protein-coding regions of the genome. This high depth ensures robust detection of single nucleotide variants and small indels in the genes most often associated with disease.
This combination makes BGE an ideal solution for robust genetic discoveries.
💡💡Clinically Ready, Affordable
The key benefit of the BGE product is its affordability relative to obtaining both a high-coverage whole genome and a high-coverage whole exome separately. This makes it an efficient option for both large-scale research projects and practical clinical applications.
Important Note: The underlying sequencing data has already been clinically validated in the lab. The BGE product can be utilized for:
- Research Use Only (RUO): An excellent platform for cost-effective, large-cohort genetic discovery.
- Clinical Purposes: With an additional dry lab validation step, the data can be used for clinical testing, providing a comprehensive and affordable diagnostic option.
The Blended 3X Low Pass Genome + 40X Whole Exome (BGE) offers a powerful new tool, balancing deep insight into crucial genes with broad genomic context—all while remaining accessible to a wider range of researchers and clinicians.
Gene by Gene
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Gene By Gene is a world leader in genetic testing services with over 20 years of experience. Our laboratory holds accreditation from multiple agencies, including CAP, CLIA, California Department of Public Health, and AABB. With a cutting-edge laboratory and highly trained team of experts, we are committed to excellence in the field of genetic analysis.
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